Polynucleotides are one of the most talked-about regenerative treatments in aesthetic medicine right now. While they have gained attention online, many people are still unsure what they actually are, how they work, and whether they are different from other injectable skin treatments.

If you are researching polynucleotide skin treatments, this guide explains what they are, how they improve skin quality, and why they are becoming an increasingly popular option for natural skin rejuvenation.

What Are Polynucleotides?

Polynucleotides are purified fragments of DNA that are used in regenerative medicine to support skin repair and renewal. In aesthetic treatments, they are injected into the skin to stimulate healing, improve hydration, and encourage collagen production.

You may also see polynucleotides referred to online as “salmon sperm injections.” This is because the DNA fragments used in polynucleotide treatments are derived from purified salmon DNA. The term can sound unusual, but the material is carefully processed and purified to make it safe and highly compatible with human tissue.

The reason salmon DNA is used is because its molecular structure is extremely similar to human DNA, making it effective for supporting skin regeneration.

How Polynucleotides Improve Skin

Unlike dermal fillers, polynucleotides do not add volume or change facial shape. Instead, they work by improving the health and structure of the skin itself.

Their main effects include:

• Stimulating collagen and elastin production

• Improving skin hydration

• Supporting cellular repair and regeneration

• Reducing inflammation in the skin

• Improving elasticity and firmness

Over time, this leads to skin that appears smoother, healthier, and more resilient.

What Skin Concerns Can Polynucleotides Treat?

Polynucleotide treatments are particularly effective for improving overall skin quality and addressing early signs of ageing.

They are commonly used for:

• Fine lines and early wrinkles

• Thin or fragile skin

• Under-eye crepiness or dark circles

• Loss of skin elasticity

• Dull or tired looking skin

One of the most popular areas for treatment is the under-eye area, where polynucleotides can improve skin thickness and hydration without the risks associated with under-eye filler.

How Polynucleotides Differ From Fillers and Skin Boosters

Polynucleotides are often confused with other injectable treatments, but they work differently.

Dermal fillers are designed to restore volume or reshape areas of the face.

Skin boosters mainly improve hydration within the skin.

Polynucleotides, on the other hand, focus on regeneration. They encourage the skin to repair itself, making them an excellent option for those who want natural improvements in skin quality rather than structural change.

When Will You See Results?

Polynucleotide treatments work by stimulating the body’s natural repair processes, so results develop gradually rather than instantly.

Most treatment plans involve a course of sessions spaced several weeks apart. Improvements in skin hydration and texture can often be noticed within a few weeks, with continued collagen stimulation over the following months.

Are Polynucleotides Safe?

Polynucleotides have been widely used in regenerative medicine for many years and have a strong safety profile when administered by trained medical professionals.

Because the DNA fragments are highly purified, the risk of allergic reaction is extremely low. Treatments are minimally invasive and involve small injections placed into the skin.

Is This Treatment Right for You?

Polynucleotides are ideal for people who want to improve skin quality in a natural way without adding volume or dramatically altering their appearance. They are particularly useful for areas where the skin is delicate, such as the under-eye area.

At PureMed Aesthetics, treatments are always tailored to the individual. A consultation allows us to assess your skin concerns and recommend the most appropriate treatment plan.

If you are interested in polynucleotide skin treatments in the UK, a consultation is the best place to start. Click here to arrange a consultation with us, we look forward to seeing you!